PhD students

Termin ważności: 2017-01-02 - 2017-02-02 Thumb_instytutchemiibioorganicznej
Województwo / region Wielkopolskie
Firma Institute of Bioorganic Chemistry PAS
Opis

Two PhD student positions are available at the Department of Molecular Biomedicine, Institute of Bioorganic Chemistry PAS in Poznan.

NCN Project OPUS10: “Role of microRNAs in regulation iron metabolism in Friedreich's ataxia

Friedreich's ataxia (FRDA) is the most frequent inherited form of ataxia in humans. The most common FRDA symptoms include muscle weakness and loss of coordination, vision impairment and hearing loss, heart muscle abnormalities, scoliosis, and diabetes. First symptoms can usually be noticed between the ages of 5 and 15 and they progressively worsen with time. Cardiac failure is the primary cause of death in FRDA patients. The goals of this project are to define changes in the expression and activity of microRNAs in FRDA, and analyze how these abnormalities affect the activity of genes which are responsible for the localization and amount of iron in neuronal and heart cells of patients with Friedreich’s ataxia. We will define relationship between miRNA molecules and iron availability.  We will also uncover the pattern of detectable microRNA molecules that is specific to FRDA. This “microRNA signature” characteristic for FRDA will help to evaluate the effectiveness of therapeutic approaches intended to increase activity of the frataxin gene or to regulate distribution of iron in neurons and cardiac cells of FRDA patients. Misregulated microRNAs as well as genes under their control may also become new targets for therapeutic intervention in FRDA.

 

Qualificatons

The specific experience expected from the candidates includes considerable skills in one or more of the following areas:

  • Cellular and molecular biology
  • Cell culture techniques including human pluripotent stem cells, lymphoblasts and fibroblasts
  •  Transcriptomic techniques especially of small RNAs (miRNAs)
  • Experience in bioinformatics and analysis of data obtained from high-throughput transcriptomic analyses

The candidates will be evaluated on the basis of scientific excellence criteria, previous experience in research and their publication record.


Salary

The monthly salary for the PhD student is 3000 PLN. Scheduled employment period March 1, 2017 – May 31, 2019.


How to apply

The applications containing motivation letter, CV, publication list and reference letter/s, written either in English or Polish, should be mailed to Professor Marek Napierala at mnapiera@uab.edu or Professor Wlodzimierz Krzyzosiak wlodkrzy@ibch.poznan.pl by January 31st 2017. The best candidates will receive invitation for an interview combined with delivering a brief talk at DMB IBCh PAS by February  14th. The successful candidates will be informed about the DMB positive decision not later than by February 15th.


Additional information

Website: http://www.ibch.poznan.pl/pl/main-pl/struktura/zaklad-biomedycyny-molekularnej/

Please include in your application the following statement: “In accordance with the personal data protection act from the 29th of August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes”.

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WsteczStyczeń 2017Dalej

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Warsztaty o grantach ERC
2017-01-13 do 2017-01-13
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Nowości w cukrzycy
2017-01-14 do 2017-01-14
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